Ib pab neeg tshawb fawb coj los ntawm Prof. XUE Tian thiab Prof. MA Yuqian los ntawm University of Science thiab Technology ntawm Tuam Tshoj (USTC), koom tes nrog ntau pab pawg tshawb fawb, tau ua tiav cov neeg nyob ze-infrared (NIR) spatiotemporal xim pom kev los ntawm upconversion contact lenses (UCLs). Txoj kev tshawb no tau luam tawm online hauv Cell thaum Lub Tsib Hlis 22, 2025 (EST), thiab tau tshaj tawm hauv Xov Xwm Tshaj Tawm los ntawmCell Xovxwm.
Nyob rau hauv qhov xwm txheej, electromagnetic nthwv dej nthuav dav dav ntawm wavelengths, tab sis tib neeg lub qhov muag tuaj yeem pom tsuas yog ib feem nqaim hu ua lub teeb pom kev, ua rau NIR lub teeb dhau ntawm qhov kawg liab ntawm lub spectrum pom tsis tau rau peb.
Fig1. Electromagnetic nthwv dej thiab pom lub teeb spectrum (Duab los ntawm Prof. XUE's team)
Hauv xyoo 2019, ib pab neeg coj los ntawm Prof. XUE Tian, MA Yuqian, thiab HAN Gang tau ua tiav los ntawm kev txhaj tshuaj upconversion nanomaterials rau hauv cov tsiaj retinas, ua rau thawj qhov muag liab qab NIR lub ntsej muag muaj peev xwm hauv cov tsiaj nyeg. Txawm li cas los xij, vim muaj kev txwv tsis pub siv ntawm kev txhaj tshuaj intravitreal hauv tib neeg, qhov kev sib tw tseem ceeb rau cov thev naus laus zis no nyob rau hauv kev ua kom tib neeg kev nkag siab ntawm NIR lub teeb los ntawm txoj kev tsis cuam tshuam.
Cov ntsej muag pob tshab uas ua los ntawm cov khoom siv polymer muab cov kev daws teeb meem hnav, tab sis tsim UCLs ntsib ob qhov teeb meem tseem ceeb: ua kom muaj peev xwm hloov tau zoo, uas yuav tsum muaj kev hloov pauv nanoparticles siab (UCNPs) doping, thiab tswj kom pom tseeb. Txawm li cas los xij, koom nrog nanoparticles rau hauv cov polymers hloov lawv cov khoom kho qhov muag, ua rau nws nyuaj rau kev sib npaug siab nrog qhov pom tseeb.
Los ntawm kev hloov kho saum npoo ntawm UCNPs thiab kev tshuaj xyuas ntawm cov khoom siv refractive-index-matched polymeric cov ntaub ntawv, cov kws tshawb fawb tsim UCLs ua tiav 7-9% UCNP kev koom ua ke thaum tuav ntau dua 90% pob tshab hauv qhov pom spectrum. Tsis tas li ntawd, UCLs tau pom qhov ua tau zoo ntawm kev kho qhov muag, hydrophilicity, thiab biocompatibility, nrog cov txiaj ntsig kev sim qhia tias ob qho tib si murine qauv thiab tib neeg hnav tuaj yeem tsis tsuas ntes NIR lub teeb tab sis kuj sib txawv nws lub sijhawm ntawm lub cev.
Qhov zoo tshaj plaws, pab pawg tshawb fawb tau tsim lub ntsej muag looj ntsej muag ua ke nrog UCLs thiab kho qhov muag pom kev zoo kom kov yeej cov kev txwv uas UCLs tsuas yog muab cov neeg siv nrog kev nkag siab ntawm NIR cov duab. Qhov kev nce qib no ua rau cov neeg siv nkag siab txog NIR cov duab nrog kev daws teeb meem spatial piv rau qhov pom lub teeb pom kev zoo, tso cai rau kev paub tseeb dua ntawm cov qauv NIR nyuaj.
Txhawm rau tiv thaiv kev nthuav dav ntawm ntau lub teeb pom kev zoo NIR hauv ib puag ncig ntuj, cov kws tshawb fawb tau hloov cov tshuaj UCNPs nrog trichromatic UCNPs los tsim trichromatic upconversion contact lo ntsiab muag (tUCLs), uas ua rau cov neeg siv paub qhov txawv peb NIR wavelengths thiab pom qhov dav NIR xim spectrum. Los ntawm kev sib koom ua ke cov ntaub ntawv xim, sab cev nqaij daim tawv, thiab qhov chaw, tUCLs tso cai rau kev lees paub meej ntawm cov ntaub ntawv NIR-encoded multi-dimensional, muab kev txhim kho spectral xaiv thiab muaj peev xwm tiv thaiv kev cuam tshuam.
Fig 2. Cov xim zoo nkauj ntawm ntau cov qauv (simulated reflective iav nrog sib txawv reflection spectra) nyob rau hauv pom thiab NIR illumination, raws li tau pom los ntawm cov looj tsom iav uas siv tau nrog tUCLs. (Duab los ntawm Prof. XUE's team)
Fig 3. UCLs pab tib neeg kev nkag siab ntawm NIR lub teeb nyob rau hauv lub cev, qhov ntev, thiab chromatic qhov ntev. (Duab los ntawm Prof. XUE's team)
Txoj kev tshawb no, uas tau qhia txog kev hnav khaub ncaws rau NIR lub zeem muag hauv tib neeg los ntawm UCLs, tau muab cov ntaub ntawv pov thawj ntawm lub tswv yim rau NIR xim tsis pom kev thiab qhib cov ntawv cog lus hauv kev ruaj ntseg, tiv thaiv cuav, thiab kho cov xim tsis pom kev.
Daim ntawv txuas:https://doi.org/10.1016/j.cell.2025.04.019
(Sau los ntawm XU Yehong, SHEN Xinyi, Edited los ntawm ZHAO Zheqian)
Post lub sij hawm: Jun-07-2025